1381886-79-8

Basic information

• Product Name: N-(3-(3-fluorophenyl)propyl)-7-azabicyclo[2.2.1]heptane
• Synonyms: N-(3-(3-fluorophenyl)propyl)-7-azabicyclo[2.2.1]heptane
• CAS NO: 1381886-79-8
• Molecular Weight: 233.329
• Mol File: 1381886-79-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-(3-fluorophenyl)propyl)-7-azabicyclo[2.2.1]heptane(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-(3-fluorophenyl)propyl)-7-azabicyclo[2.2.1]heptane(1381886-79-8)
• EPA Substance Registry System: N-(3-(3-fluorophenyl)propyl)-7-azabicyclo[2.2.1]heptane(1381886-79-8)

Safety Data

• Hazardous Substances Data: 1381886-79-8(Hazardous Substances Data)

Upstream product

• 1381886-75-4 1-(7-azabicyclo[2.2.1]heptanyl)-3-(3-fluorophenyl)propanone 
• 1267754-61-9 C₁₂H₁₁FN₂O 
• 27514-07-4 7-azabicyclo[2.2.1]heptane hydrochloride 
• 458-45-7 3-(3-fluorophenyl)propionic acid 

Relevant articles and documents

7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands

A series of N-substituted 7-azabicyclo[2.2.1]heptanes (12-17 and 22-25) and similarly substituted pyrrolidines (32-36 and 41-44) were synthesized as sterically-reduced, achiral analogs of adamantane- and trishomocubane-derived σ ligands. In vitro competition binding assays against σ receptors revealed that arylalkyl N-substituents conferred selectivity for the σ2 subtype, while alicyclic or polycarbocyclic substituents imparted high affinity for both subtypes. The σ2 binding and subtype selectivities of N-arylalkyl-7-azanorbornanes was generally greater than the analogously-substituted pyrrolidines, indicating that steric bulk and conformational restriction around the nitrogen atom are likely important for subtype discrimination.