138196-41-5Relevant academic research and scientific papers
Catalyst-controlled Wacker-type oxidation of protected allylic amines
Michel, Brian W.,McCombs, Jessica R.,Winkler, Andrea,Sigman, Matthew S.
supporting information; experimental part, p. 7312 - 7315 (2010/11/05)
On the contrary: Utilizing the [Pd-(quinox)]-TBHP catalyst system, protected allylic amines were oxidized with high selectivity for the methyl ketone product. This is contrary to the results obtained by the substrate-controlled Tsuji-Wacker oxidation, which highlights the catalyst-controlled system presented here (see scheme). A variety of N-pro-tecting groups undergo selective oxidation with high ketone selectivity. TBHP = tert-butylhydroperoxide.
