1381963-73-0Relevant academic research and scientific papers
Palladium(II)-catalyzed direct alkenylation of nonaromatic enamides
Gigant, Nicolas,Gillaizeau, Isabelle
, p. 3304 - 3307 (2012)
A mild and efficient method for the direct alkenylation of nonaromatic enamides was achieved through a palladium(II)-catalyzed C-H functionalization. The reaction scope includes cyclic and acyclic enamides and a range of activated alkenes. This approach represents the first successful direct C(3)-functionalization of nonaromatic cyclic enamides.
Direct alkenylation of non-aromatic enamides via palladium-catalyzed oxidative coupling: Synthetic developments and applications
Gigant, Nicolas,Chausset-Boissarie, La?titia,Rey-Rodriguez, Romain,Gillaizeau, Isabelle
, p. 358 - 362 (2013/08/25)
Direct C(3) alkenylation of non-aromatic enamides through palladium(II)-catalyzed Fujiwara-Moritani cross-coupling was developed. The reaction scope includes a range of cyclic enamides as well as activated alkenes. The utility of this methodology is illustrated by the synthesis of octa- or tetrahydroquinoline cores obtained from conjugated enamides via Diels-Alder cycloaddition.
