1381969-27-2Relevant academic research and scientific papers
Synthesis and anticancer activity of 5,6,8,13-tetrahydro-7Hnaphtho[2,3-a] [3]-benzazepine-8,13-diones
Phutdhawong, Weerachai,Eksinitkun, Gedsirin,Ruensumran, Wanwikar,Taechowisan, Thongchai,Phutdhawong, Waya S.
, p. 769 - 777 (2012)
A series of naphthoquinones fused benzazepines, 5,6,8,13-tetrahydro-7H- naphtho[2,3-a][3]- benzazepine-8,13-diones, were synthesized and evaluated for their anticancer activity against four cell lines; human breast carcinoma cell line, human cervix carcinoma cell line, human hepatocellular carcinoma cell line and human keratinocyte cell line. The results showed that 5,6,8,13-tetrahydro- 2,3,4,9-tetramethoxy-7H-naphtho[2,3-a][3]benzazepine-8,13-dione 4g and 5,6,8,13-tetrahydro-2,3,9-trimethoxy-7H-naphtho[2,3-a][3]benzazepine-8,13-dione 4h have significant cytotoxicity against a hepatocellular carcinoma cell line with IC50 = 3.5 μg/mL and 3.0 μg/mL, respectively.
