1381983-19-2

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 21473-01-8 2-naphthalenylmagnesium bromide 
• 945034-28-6 3,4,5-(trimethoxyphenyl)(naphthalen-6-yl)methanol 

Downstream Products

• 1381982-98-4 2,2,5-trimethyl-5-(naphthalen-2-yl(3,4,5-trimethoxyphenyl)methyl)-1,3-dioxane-4,6-dione 

Relevant academic research and scientific papers

Carbon-based leaving group in substitution reactions: Functionalization of sp3-hybridized quaternary and tertiary benzylic carbon centers

Lewis acid promoted substitution reactions employing Meldrum's acid and 5-methyl Meldrum's acid as carbon-based leaving groups are described which transform unstrained quaternary and tertiary benzylic Csp 3-Csp3 bonds into Csp3-X bonds (X = C, H, N). Importantly, this reaction has a broad scope in terms of both suitable substrates and nucleophiles with good to excellent yields obtained (typically >90%).