138206-99-2Relevant academic research and scientific papers
Synthesis, pharmacological investigation and computational studies on a tricyclic ergoline analog with selective dopamine autoreceptor activity
Gmeiner,Bollinger,Mierau,Hofner
, p. 609 - 614 (2007/10/03)
The novel aminobenzindolone 8 was prepared and evaluated as a potential antipsychotic agent. The target compound was synthesized in eight steps starting from the tetrahydrobenzindolone 9. The key step of the synthesis was an electrophilic amination of the
Efficient Methodology for the Preparation of β-Aminotetralin Derivatives via Electrophilic Amination
Gmeiner, Peter,Bollinger, Bernd
, p. 5927 - 5930 (2007/10/02)
A mild and efficient method for the construction of β-aryl amines from the corresponding α-aryl ketones is presented.The key step of the synthesis involve an electrophilic amination by dibenzyl azodicarboxylate followed by a stereoselective LiHBEt3 reduction.The reaction sequence is applied to the synthesis of the tricyclic ergoline analogue 4. Key words: electrophilic amination; stereoselective reduction; α-amino ketones.
