138219-56-4

Upstream product

• 402-55-1 4-fluorosulfonylbenzoyl chloride 
• 102742-20-1 2-amino-4'-dimethylaminoacetophenone hydrochloride 
• 152278-02-9 4-[2-(4-Dimethylamino-phenyl)-2-oxo-ethylcarbamoyl]-benzenesulfonyl fluoride 

Downstream Products

• 138219-55-3 dapoxylsulfonyl chloride 
• 203250-31-1 N-(2-aminoethyl)-4-[5-(4-dimethylaminophenyl)oxazol-2-yl]benzenesulfonamide 
• 203250-34-4 3-{4-[5-(4-Dimethylamino-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-propionic acid 
• 203250-33-3 3-{4-[5-(4-Dimethylamino-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-propionic acid ethyl ester 
• 203250-35-5 dapoxil 3-sulfonamidopropionic acid succinimidyl ester 

Relevant academic research and scientific papers

Fluorescent Molecular Probes II. The Synthesis, Spectral Properties and Use of Fluorescent Solvatochromic Dapoxyl Dyes

2,5-Diphenyloxazoles that embody a dimethylamino group at position 4 of the 5-phenyl ring and a sulfonyl group at position 4 of the 2-phenyl ring were prepared as new fluorescent solvatochromic dyes. In these molecules, there is a "push-pull" electron transfer system from the 5-phenyl moiety to the 2-phenyl ring. These compounds show strong solvent-dependent fluorescence that is well correlated with the empirical solvent polarity parameter ET (30). The solvent polarity dependence suggests that the fluorescence arises from an intramolecular charge transfer. The fluorescence-environment dependence, long emission wavelength, large extinction coefficients, high fluorescence quantum yields and large Stokes shift of the fluorophores can be used to develop ultrasensitive fluorescent molecular probes to study a variety of biological events and processes.

4-(5-ARYL-2-OXAZOLYL)BENZENESULFONIC ACID DERIVATIVES CONTAINING A DIMETHYLAMINO GROUP

Condensation of 4-chlorosulfonyl- and 4-fluorosulfonyl-benzoyl chlorides with p-dimethylamino-α-aminoacetophenone followed by cyclodehydration of the resulting amides leads to the formation of 4-(5-dimethylaminophenyl-2-oxazolyl)benzenesulfonyl halides, and the corresponding sulfonic ester, sulfomorpholide, sulfonamide, and sodium salt are synthesized from them.The spectral and luminescence properties of the compounds synthesized have been studied in toluene, ethanol, DMF.The ability of the sulfonyl group to transmit the electronic effects of the substituents on it to the overall molecular ?-electron system of 2,5-diaryloxazole has been demonstrated.Solvation fluorochromia has been detected in polar solvents.In some of the compounds studied the Stokes shift exceeds 200 nm.