138222-97-6

Basic information

• Product Name: [1-(4-Chloro-phenyl)-2,5-dimethyl-1H-pyrrol-3-ylmethyl]-phenyl-amine
• Synonyms: [1-(4-Chloro-phenyl)-2,5-dimethyl-1H-pyrrol-3-ylmethyl]-phenyl-amine
• CAS NO: 138222-97-6
• Molecular Weight: 310.826
• Mol File: 138222-97-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [1-(4-Chloro-phenyl)-2,5-dimethyl-1H-pyrrol-3-ylmethyl]-phenyl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(4-Chloro-phenyl)-2,5-dimethyl-1H-pyrrol-3-ylmethyl]-phenyl-amine(138222-97-6)
• EPA Substance Registry System: [1-(4-Chloro-phenyl)-2,5-dimethyl-1H-pyrrol-3-ylmethyl]-phenyl-amine(138222-97-6)

Safety Data

• Hazardous Substances Data: 138222-97-6(Hazardous Substances Data)

Usage

General Description

[1-(4-Chloro-phenyl)-2,5-dimethyl-1H-pyrrol-3-ylmethyl]-phenyl-amine is a chemical compound with a complex molecular structure. It is composed of a 1H-pyrrol-3-ylmethyl group attached to a phenyl-amine molecule, along with a 4-chloro-phenyl and 2,5-dimethyl substituents. [1-(4-Chloro-phenyl)-2,5-dimethyl-1H-pyrrol-3-ylmethyl]-phenyl-amine may have potential pharmacological or industrial applications, as its structure suggests potential biological activity or chemical reactivity. However, further research and testing would be necessary to fully understand the properties and potential uses of this chemical.

Upstream product

• 110-13-4 2,5-hexanedione 
• 20461-26-1 1-(4-chlorophenyl)-2, 5-dimethyl-1H-pyrrole-3-carbaldehyde 
• 62-53-3 aniline 
• 5044-23-5 1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrole 
• 138222-75-0 [1-[1-(4-Chloro-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-meth-(E)-ylidene]-phenyl-amine 

Relevant articles and documents

Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: Structure-activity relationships and mode of action studies

Antibiotic resistance represents a major threat worldwide. Gram-positive and Gram-negative opportunistic pathogens are becoming resistant to all known drugs mainly because of the overuse and misuse of these medications and the lack of new antibiotic development by the pharmaceutical industry. There is an urgent need to discover structurally innovative antibacterial agents for which no pre-existing resistance is known. This work describes the identification, synthesis and biological evaluation of a novel series of 1,5-diphenylpyrrole compounds active against a panel of ESKAPE bacteria. The new compounds show high activity against both wild type and drug-resistant Gram + ve and Gram-ve pathogens at concentrations similar or lower than levofloxacin. Microbiology studies revealed that the plausible target of the pyrrole derivatives is the bacterial DNA gyrase, with the pyrrole derivatives displaying similar inhibitory activity to levofloxacin against the wild type enzyme and retaining activity against the fluoroquinolone-resistant enzyme.