138230-56-5

Upstream product

• 26171-50-6 (S)-3-dimethylamino-2-methyl-1-phenyl-propan-1-one 
• 91-03-2 3-dimethylamino-2-methyl-1-phenyl-propan-1-one 
• 5400-92-0 3-dimethylamino-2-methyl-1-phenyl-propan-1-one; hydrochloride 
• 48141-77-1 3-(dimethylamino)-2-methyl-1-phenyl-propanon 
• 93-55-0 1-phenyl-propan-1-one 
• 20428-71-1 threo-3-hydroxy-3-phenyl-2,N,N-trimethylpropionamide 
• 76454-71-2 (2S,3R)-3-Hydroxy-2,N,N-trimethyl-3-phenyl-thiopropionamide 
• 5309-94-4 N,N-Dimethyl-thiopropionamide 
• 100-52-7 benzaldehyde 
• 20428-71-1 (2RS,3RS)-3-hydroxy-N,N,2-trimethyl-3-phenylpropanamide 
• 76454-71-2 (2S,3S)-3-Hydroxy-2,N,N-trimethyl-3-phenyl-thiopropionamide 
• 108471-82-5 N,N,2-trimethyl-3-oxo-3-phenylpropanamide 
• 138060-82-9 1-Phenyl-1-<(S)-2-(methoxymethyl)-1-pyrrolidyl>-1-propen 

Downstream Products

• 80792-41-2 Carbonic acid 3-dimethylamino-2-methyl-1-phenyl-propyl ester phenyl ester; hydrochloride 
• 74184-99-9 erythro-3-Hydroxy-2-methyl-3-phenylpropyltrimethylammoniumiodid 
• 74184-99-9 threo-3-Hydroxy-2-methyl-3-phenylpropyltrimethylammoniumiodid 
• 66063-97-6 Carbamic acid 3-dimethylamino-2-methyl-1-phenyl-propyl ester 
• 100-52-7 benzaldehyde 

Relevant academic research and scientific papers

One-pot highly stereoselective reduction of β-keto amides to syn-γ-aminols

In the presence of titanium tetrachloride, the borane/tetrahydrofuran complex can reduce 2-methyl-3-oxoamides into the corresponding syn-aminols in good yields and high diastereoselectivity. The use of borane/dimethyl sulfide instead of BH3/THF

Stereocontrolled Syntheses of Mannich Bases and γ-Amino Alcohols

The reaction of enantiomerically pure SMP enamines 2 with iminium tetrachloroaluminates 3 yields optically active Mannich bases 4.Diastereoselective reduction of 4 gives γ-amino alcohols 5 with the desired configuration. Key Words: Mannich bases / Enamines / Iminium salts / γ-Amino alcohols

SUR LES ORGANOMETALLIQUES ISSUS DE THIOAMIDES. I. REACTIVITE AVEC LES ALDEHYDES ET CETONES; STEREOCHIMIE DE LA CONDENSATION AVEC LA t-BUTYL-4 CYCLOHEXANONE ET LE BENZALDEHYDE

Organometallic compounds derived from thioamides RCH2CSN(R3)2 condense normally with aldehydes and saturated ketones.Condensation with 4-t-butylcyclohexanone leads predominantly to equatorial attack by the organometallic compound.These results suggest that the organometallic structure is RCH=C(SM)N(R3)2.The stereoselectivity of the reaction with benzaldehyde depends on R and R3; a mechanism for the formation of β-hydroxythioamides is discussed.

Transformation of Acyclic Ketones into Aldehydes and Ketones with Substituted Side Chains

Aminomethylation of the acyclic ketones 1/2 leads to the aminoketones 3/4 which give, after reduction, quaternisation and ion exchange or previous reaction with a Grignard reagent, the hydroxyammonium compounds 9/10 and 14, respectively.Flash thermolysis of 9/10 yields the aldehydes 7 and of 14 the ketone 15 in which one side-chain of the educt 2b is substituted by the alkyl group of the Grignard reagent.