138236-25-6Relevant academic research and scientific papers
An efficient synthesis of peri-hydroxy aromatic compounds via a strong- base-induced [4+2] cycloaddition of homophthalic anhydrides with enolizable enones
Iio, Kiyosei,Ramesh, Namakkal G.,Okajima, Akiko,Higuchi, Kazuhiro,Fujioka, Hiromichi,Akai, Shuji,Kita, Yasuyuki
, p. 89 - 95 (2007/10/03)
An efficient synthesis of peri-hydroxy aromatic compounds has been accomplished via a strong-base-induced [4+2] cycloaddition of homophthalic anhydrides with α-sulfinyl-substituted derivatives of enolizable enones. The unsubstituted enones did not undergo an efficient [4+2] cycloaddition reaction with homophthalic anhydrides, presumably due to their enolization under the basic reaction conditions. The sulfinyl group not only promotes the cycloaddition reaction but also undergoes in situ elimination under the reaction conditions to afford the peri-hydroxy aromatic compounds in a single step. The application of this methodology for the synthesis of a key intermediate of antitumor antibiotic fredericamycin A is described. PM3 calculations of various 2-substituted cyclopentenones as well as the mechanism of the cycloaddition are also discussed.
Azepine derivatives useful as nitric oxide synthase inhibitors
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, (2008/06/13)
The current invention discloses azepine derivatives useful as nitric oxide synthase inhibitors.
Facile cleavage of N.N-dimethylhydrazones to ketones using tetrabutylammonium peroxydisulfate
Hyun Chul Choi,Yong Hae Kim
, p. 2307 - 2311 (2007/10/02)
Tetrabutylammonium peroxydisulfate is turned out to be a good reagent for the conversion of N,N-dimethylhydrazones to ketones.
Intramolecular anodic olefin coupling reactions: The use of bis enol ether substrates
Moeller, Kevin D.,Tinao, Luzviminda V.
, p. 1033 - 1041 (2007/10/02)
In an effort to develop electrochemical methods for directly initiating oxidative cyclization reactions, the anodic oxidation of bis enol ether substrates has been examined. The reactions were found to lead to the formation of five-, six-, and seven-membered-ring 1,4-dicarbonyl equivalents. The reactions were not found to be useful for generating larger ring sizes. Both alkyl and silyl enol ether substrates were found to be compatible with the conditions required for carbon-carbon bond formation. Cyclic voltammetry studies indicated that the cyclizations were fast and that the reactions happened at or near the electrode surface. Finally, the cyclization reactions were shown to be compatible with the formation of quaternary carbons, even when carbon-carbon bond formation involved the generation of two vicinal quaternary carbons.
