138240-22-9

Upstream product

• 1227858-69-6 C₂₂H₁₉N₃O₅ 
• 104-94-9 4-methoxy-aniline 
• 874-90-8 4-methoxybenzonitrile 

Downstream Products

• 935750-29-1 4-(2-chloro-4-methoxyphenyl)-1,2-bis(4-methoxyphenyl)-5-methyl-1H-imidazole 
• 935750-38-2 5-ethyl-1,2-bis(4-methoxyphenyl)-1H-imidazole 
• 935750-32-6 5-ethyl-1,2-bis(4-methoxyphenyl)-4-phenyl-1H-imidazole 
• 1157-63-7 6-methoxy-2-(4-methoxyphenyl)-quinazolin-4(3H)-one 
• 792930-72-4 4-ethoxycarbonyl-1-(4-methoxyphenyl)-2-(4-methoxyphenyl)-1H-imidazole 
• 935750-27-9 1,2,4-tris(4-methoxyphenyl)-5-methyl-1H-imidazole 
• 935750-35-9 1,2,4-tris(4-methoxyphenyl)-5-phenyl-1H-imidazole 
• 21124-73-2 1,2,4,5-tetrakis(4-methoxyphenyl)-1H-imidazole 
• 868861-15-8 1,2,4-tris(4-methoxyphenyl)-1H-imidazole 
• 868861-16-9 4-(2-chloro-4-methoxyphenyl)-1,2-bis(4-methoxyphenyl)-1H-imidazole 
• 868861-18-1 5-ethyl-1,2,4-tris(4-methoxyphenyl)-1H-imidazole 
• 868861-19-2 1,2-bis(4-methoxyphenyl)-4-(trifluoromethyl)-1H-imidazole 

Relevant academic research and scientific papers

Calcium mediated efficient synthesis ofN-arylamidines from organic nitriles and amines

Amidines are a preeminent group of organic compounds having wide applications in various industries. Here, we have developed a simple one-step reaction protocol for the facile synthesis ofN-arylamidines catalysed by calcium bis(hexamethyldisilazide) [Ca{N

Synthesis of 2-arylquinazolin-4(3H)-ones by N-aryl benzamidines with aromatic carbonates

The reaction of N-aryl benzamidines 1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h, 1i, 1j, 1k, 1l, 1m, 1n with diphenyl carbonate 2a or ethyl phenyl carbonate 2b synthesized 2-arylquinazolin-4(3H)-ones 3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h, 3i, 3j, 3k, 3l, 3m, 3n in simple and

An efficient route towards the synthesis of monosubstituted N-aryl amidines from 4,5-Dihydro-1,2,4-oxadiazoles

4,5-Dihydro-1,2,4-oxadiazoles were prepared using 1,3-dipolar cycloaddition of imines with nitrile oxides. Further reductive N-O bond cleavage furnished monosubstituted N-aryl amidines in good yield. Thus an efficient route for the synthesis of monosubsti

Structure-activity relationship study to understand the estrogen receptor-dependent gene activation of aryl- and alkyl-substituted 1H-imidazoles

A series of C5-substituted 1,2,4-triaryl-1H-imidazoles was synthesized. Their gene-activating properties were determined on estrogen receptor alpha positive MCF-7 breast cancer cells, stably transfected with the plasmid ERE wtcluc (MCF-7-2a cells). The influence of 4-OH and 2-Cl substituents on the phenyl rings as well as the significance of a methyl, ethyl, or phenyl group at C5 on the estrogen receptor binding and the resulting gene activation in MCF-7-2a cells was studied. The alkyl and aryl groups at C5 of 1,2,4-tris(4-hydroxyphenyl)-1H-imidazole 1 increased the transactivation, while chlorine atoms on the phenyl rings diminished this effect. 5-Ethyl-1,2,4-tris(4- hydroxyphenyl)-1H-imidazole 9 was identified as the most active compound. Its excellent transcriptional activity did not only depend on the C5 ethyl group, but also on the three hydroxyl groups of the phenyl rings. Compounds (11-14) with a reduced number of hydroxyl groups displayed distinctly lower gene activation.

Synthesis and pharmacological evaluation of 1H-imidazoles as ligands for the estrogen receptor and cytotoxic inhibitors of the cyclooxygenase

The 1H-imidazoles 7a-e were synthesized and tested for biological activity in vitro. The results pointed to a clear structure-activity relationship. The introduction of an ethyl chain at C5 of the 1,2,4-tris(4-hydroxyphenyl)-1H- imidazole 7 a caused hormo

Reactions of Aryliminodimagnesium with Some N,N-Dimethylcarboxamides and Benzonitriles Affording Various Types of Amidines. Correction of Previous Results on Formamidine Formation from N,N-Dimethylformamide

Some symmetrical and unsymmetrical form- and benzamidines were prepared by the reaction of ArN(MgBr)2 with Ar'CN, HCONMe2 and related compounds in tetrahydrofuran.