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Panipenem-betamipron, also known as Carbenin, is a combination drug launched in Japan for the treatment of respiratory infections. It consists of panipenem, a semisynthetic carbapenem with potent antibacterial activity against a wide range of clinically important species of both Gram-positive and Gram-negative organisms, and betamipron, an organic anion transport inhibitor. Panipenem is more effective than imipenem and has shown to be efficacious in patients with severe infections and in children where other antibiotics were ineffective. Betamipron is formulated with panipenem in a 1:1 fixed ratio to block the incorporation of panipenem into renal tubules, thus preventing renal dysfunction.

138240-65-0

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138240-65-0 Usage

Uses

Used in Pharmaceutical Industry:
Panipenem-betamipron is used as an antibiotic for the treatment of respiratory infections caused by a wide range of clinically important species of both Gram-positive and Gram-negative organisms, including Staph. aureus, E. faecalis, and P. aeruginose. Its potent antibacterial activity and efficacy in patients with severe infections and in children where other antibiotics were ineffective make it a valuable option in the treatment of respiratory infections.
Used in Renal Protection:
Panipenem-betamipron is used as a renal protective agent to prevent renal dysfunction associated with the use of antibiotics. The inclusion of betamipron, an organic anion transport inhibitor, in the drug formulation blocks the incorporation of panipenem into renal tubules, thus providing renal protection during the treatment of respiratory infections.

Originator

Sankyo (Japan)

Check Digit Verification of cas no

The CAS Registry Mumber 138240-65-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,2,4 and 0 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 138240-65:
(8*1)+(7*3)+(6*8)+(5*2)+(4*4)+(3*0)+(2*6)+(1*5)=120
120 % 10 = 0
So 138240-65-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H21N3O4S.C10H11NO3/c1-7(19)12-10-5-11(13(15(21)22)18(10)14(12)20)23-9-3-4-17(6-9)8(2)16;12-9(13)6-7-11-10(14)8-4-2-1-3-5-8/h7,9-10,12,16,19H,3-6H2,1-2H3,(H,21,22);1-5H,6-7H2,(H,11,14)(H,12,13)/b16-8+;/t7-,9+,10-,12-;/m1./s1

138240-65-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-benzamidopropanoic acid,(5R,6S)-3-[(3S)-1-ethanimidoylpyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:138240-65-0 SDS

138240-65-0Upstream product

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