138247-68-4Relevant academic research and scientific papers
Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
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, (2008/06/13)
The present invention provides chiral nucleotide analogs having the Formulas I and II STR1 and pharmaceutically acceptable salts and solvates thereof, and their pharmaceutical compositions for use in the treatment of viral infections, especially those cau
Synthesis and antiviral activity of methyl derivatives of 9-[2- (phosphonomethoxy)ethyl]guanine
Yu,Bronson,Yang,Patick,Alam,Brankovan,Datema,Hitchcock,Martin
, p. 2958 - 2969 (2007/10/02)
A number of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG, 1) have been synthesized and tested in vitro for anti-herpes and anti- human immunodeficiency virus (HIV) activity. Among these analogues, (R)-2'- methyl-PMEG [(R)-3] and 2',2'-
