Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1382481-79-9

1382481-79-9

Post Buying Request

1382481-79-9 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1382481-79-9 Usage

Uses

ML-289 is a novel CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe derived from mGlu5 PAM (1).

Check Digit Verification of cas no

The CAS Registry Mumber 1382481-79-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,2,4,8 and 1 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1382481-79:
(9*1)+(8*3)+(7*8)+(6*2)+(5*4)+(4*8)+(3*1)+(2*7)+(1*9)=179
179 % 10 = 9
So 1382481-79-9 is a valid CAS Registry Number.

1382481-79-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail

  • Sigma

  • (SML0555)  ML289  ≥98% (HPLC)

  • 1382481-79-9

  • SML0555-5MG

  • 995.67CNY

  • Detail

  • Sigma

  • (SML0555)  ML289  ≥98% (HPLC)

  • 1382481-79-9

  • SML0555-25MG

  • 4,014.27CNY

  • Detail

1382481-79-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name [(3R)-3-(Hydroxymethyl)-1-piperidinyl]{4-[(4-methoxyphenyl)ethyny l]phenyl}methanone

1.2 Other means of identification

Product number -
Other names VU0463597 [(3R)-3-(Hydroxymethyl)-1-piperidinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]-methanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1382481-79-9 SDS

1382481-79-9Downstream Products

1382481-79-9Relevant articles and documents

Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu 5 PAM

Sheffler, Douglas J.,Wenthur, Cody J.,Bruner, Joshua A.,Carrington, Sheridan J.S.,Vinson, Paige N.,Gogi, Kiran K.,Blobaum, Anna L.,Morrison, Ryan D.,Vamos, Mitchell,Cosford, Nicholas D.P.,Stauffer, Shaun R.,Scott Daniels,Niswender, Colleen M.,Jeffrey Conn,Lindsley, Craig W.

, p. 3921 - 3925 (2012/07/14)

Herein we report the discovery and SAR of a novel metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) with 15-fold selectivity versus mGlu2. The mGlu3 NAM was discovered via a 'molecular switch' from a closely related, potent mGlu5 positive allosteric modulator (PAM), VU0092273. This NAM (VU0463597, ML289) displays an IC 50 value of 0.66 μM and is inactive against mGlu5.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1382481-79-9