1382487-16-2Relevant academic research and scientific papers
Iron Phosphate Catalyzed Asymmetric Cross-Dehydrogenative Coupling of 2-Naphthols with β-Ketoesters
Narute, Sachin,Pappo, Doron
, p. 2917 - 2920 (2017)
Chiral iron phosphate complexes were successfully exploited for asymmetric cross-dehydrogenative coupling reactions between 2-naphthols and β-ketoester derivatives. On the basis of kinetic studies, it is suggested that iron monophosphate complexes constitute the active catalysts that induce stereoselectivity during the carbon-carbon bond-formation step.
Ligand-controlled iron-catalyzed coupling of α-substituted β-ketoesters with phenols
Parnes, Regev,Kshirsagar, Umesh A.,Werbeloff, Aviya,Regev, Clil,Pappo, Doron
supporting information; experimental part, p. 3324 - 3327 (2012/09/08)
A chemo-, regio-, and stereoselective FeCl3/1,10-phenanthroline- catalyzed cross dehydrogenative coupling (CDC) reaction between phenols and α-substituted β-ketoesters was developed. The reaction creates a new quaternary carbon center within a polycyclic hemiacetal or polycyclic spirolactone architecture. The applicability of the new method to the synthesis of natural products was demonstrated by a possible biomimetic synthesis of the lachnanthospirone core.
