13826-37-4Relevant academic research and scientific papers
An efficient dehydroxymethylation reaction by a palladium catalyst
Modak, Atanu,Naveen, Togati,Maiti, Debabrata
supporting information, p. 252 - 254 (2013/02/22)
A general method for selective dehydroxymethylation has been discovered by using widely available Pd(OAc)2. The present study offers a new synthetic strategy for the regioselective functionalization by employing the steric, electronic and coordinating nature of the hydroxymethyl (-CH 2OH) group temporarily.
Nonsteroidal Antiinflammatory Agents. 1. 10,11-Dihydro-11-oxodibenzoxepinacetic Acids and Related Compounds
Nagai, Yasutaka,Irie, Akira,Nakamura, Hideo,Hino, Katsuhiko,Uno, Hitoshi,Nishimura, Haruki
, p. 1065 - 1070 (2007/10/02)
10,11-Dihydro-11-oxodibenzoxepinacetic acids and related compounds were synthesized as potential antiinflammatory agents.Among them, 2-(8-methyl-10,11-dihydro-11-oxodibenzoxepin-2-yl)propionic acid (16b) and its thiepin analogue (16c) showed excellent antipyretic activity together with potent antiinflammatory and analgesic properties in biological tests.Structure-activity relationships are discussed.
Dibenz[b,f]oxepin and dibenzo[b,f]thiepin derivatives, process for preparation thereof, method of using the same, and compositions thereof
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, (2008/06/13)
Novel dibenz[b,f]oxepin and dibenzo[b,f]thiepin derivatives of the formula STR1 wherein X is an oxygen or sulfur atom, each of R1 and R2 is a hydrogen atom or a methyl group, and R3 is a hydrogen atom or a 2-(2-hydroxyetho
