138273-91-3 Usage
Uses
1H-Isoindole-1,3(2H)-dione, hexahydro-4,7-diphenyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a valuable building block in the development of new drugs with potential therapeutic applications.
Used in Pharmaceutical Industry:
1H-Isoindole-1,3(2H)-dione, hexahydro-4,7-diphenyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]is used as a key component in the development of new drugs for the treatment of various diseases. Its structure and composition allow for the creation of molecules with specific biological activities, making it a promising candidate for drug discovery and development.
1H-Isoindole-1,3(2H)-dione, hexahydro-4,7-diphenyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]is also used as a research tool in academic and industrial laboratories. Its complex structure provides opportunities for studying the effects of different functional groups and structural modifications on the compound's properties and potential applications, contributing to the advancement of chemical and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 138273-91-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,2,7 and 3 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 138273-91:
(8*1)+(7*3)+(6*8)+(5*2)+(4*7)+(3*3)+(2*9)+(1*1)=143
143 % 10 = 3
So 138273-91-3 is a valid CAS Registry Number.
138273-91-3Relevant academic research and scientific papers
Synthesis and anxiolytic activity of N-substituted cyclic imides (1R*,2S*3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3-b icyclo[2.2.1]heptanedicarboxime (Tandospirone) and related compounds
Ishizumi,Kojima,Antoku
, p. 2288 - 2300 (2007/10/02)
A series of cyclic imides bearing a ω-(4-aryl and 4-heteroaryl-1-piperazinyl)alkyl moieties was synthesized and tested in vivo for anxiolytic activity. The in vitro binding affinities of these compounds were also examined for 5-HT(1A) receptor sites. Structure-activity relationships within these series are discussed. One of these compounds, (1R*,2S*,3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3- bicyclo[2.2.1]heptanedicarboximide (1: tandospirone), was found to be equipotent with buspirone in its anxiolytic activity and more anxio-selective than buspirone and diazepam. Tandospirone (1) is currently undergoing clinical evaluation as a selective anxiolytic agent.
