138276-15-0Relevant academic research and scientific papers
Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors
Verissimo, Edite,Berry, Neil,Gibbons, Peter,Cristiano, M. Lurdes S.,Rosenthal, Philip J.,Gut, Jiri,Ward, Stephen A.,O'Neill, Paul M.
scheme or table, p. 4210 - 4214 (2009/04/10)
The structure-based design, chemical synthesis and in vitro activity evaluation of various falcipain inhibitors derived from 2-pyridone are reported. These compounds contain a peptidomimetic binding determinant and a Michael acceptor terminal moiety capable of deactivating the cysteine protease active site.
