138277-45-9Relevant academic research and scientific papers
3R-indole methyl-6R-aromatic amino acid modified piperazine-2, 5-dione and synthesis, activity and application thereof
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Paragraph 0019; 0020, (2019/04/02)
The invention discloses a (3R, 6R)-3-(AA-amino-n-hexanoylamino-n-butyl)-6-(indole-3-methyl)-piperazine-2, 5-dione shown as a formula. AA is L-Phe (L-phenylalanine) residues and L-Trp (L-tryptophan) residues. Also disclosed are a preparation method of the
3S-indole methyl-6R-N-containing heterocyclic amino acid modified piperazine-2,5-dione, synthesis, activities and applications thereof
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Paragraph 0018; 0019, (2019/01/08)
The invention discloses (3S,6R)-3-(AA-amino-n-hexanoylamino-n-butyl)-6-(indole-3-methyl)-piperazine-2,5-dione represented by the following formula (AA is L-His residue and L-Trp residue), a preparation method, anti-tumor-metastasis activity and anti-infla
3S-indole methyl-6R-Lys modified piperazine-2,5-dione, synthesis, activities and applications thereof
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Paragraph 0018; 0019, (2019/01/08)
The invention relates to 3S-indole methyl-6R-Lys modified piperazine-2,5-dione, synthesis, activities and applications thereof, and discloses (3S,6R)-3-(Lys-amino-n-hexanoylamino-n-butyl)-6-(indole-3-methyl)-piperazine-2,5-dione represented by the followi
3 S - indole ethyl - 6S - fatty amino acid modified piperazine - 2, 5 - dione, its synthesis, activity and application (by machine translation)
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Paragraph 0019; 0020, (2019/01/06)
The invention discloses the following formula of (3 S, 6 S) - 3 - (AA - amino is hexanoyl amino-butyl) - 6 - (indole - 3 - ethyl) - piperazine - 2, 5 - dione (in the formula AA is L - Ala residue, Gly residue, L - Met residue, L - IIe residue, L - Pro residue, L - Val residues and L - Leu residues). Discloses a process for their preparation, has disclosed their anti-tumor activity, discloses their anti-tumor activity, and has disclosed their anti-inflammatory activity activity, the present invention thus discloses in the preparation of anti-tumor drug, anti-tumor metastasis drug and anti-inflammatory drug in the application. (by machine translation)
3S-indolylethyl-6S-aromatic amino acid-modified piperazidine-2,5-dione and synthesis, activity and application thereof
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Paragraph 0019; 0020, (2019/01/08)
The invention discloses (3S,6S)-3-(AA-amino-n-hexanoylamino-n-butyl)-6-(indolyl-3-ethyl)-piperazidine-2,5-dione, and a preparation method, antitumor activity, antitumor metastasis activity and anti-inflammatory activity thereof. The compounds are shown in a following formula, wherein AA is L-Phe residues, L-Tyr residues and L-Trp residues. Thus the invention discloses application of the compoundsin preparation of antitumor drugs, antitumor metastasis drugs and anti-inflammatory drugs.
(3S,6S)-3,6 disubstituted piperazine-2,5-dione, and preparation method and therapeutic effect thereof
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Paragraph 0022; 0023, (2016/11/14)
The invention discloses a u-PA inhibitor, i.e., (3S,6S)-3-(4-butylamino)-6-(indol-3-ethyl)-piperazine-2,5-dione, a preparation method thereof, an effect thereof in inhibiting tumor cell invasion and migration, and an effect thereof in hemostasis and anti-inflammation. The invention belongs to the field of biomedicine.
Solution-phase automated synthesis of tripeptide derivatives
Kuroda,Hattori,Kitada,Sugawara
, p. 1138 - 1146 (2007/10/03)
An improved general method for automated synthesis of tripeptides was developed, in which methanesulfonic acid (MSA) was used in place of trifluoroacetic acid (TFA), thus making it possible to avoid, 1) corrosion of the apparatus by strong acid vapor, 2) formation of emulsions, and 3) use of the restricted solvent, dichloromethane. As an application of the automated synthesis apparatus, 216 fragment tripeptide derivatives were synthesized systematically using the MSA method, in excellent yield and with increased efficiency.
