1382997-68-3Relevant academic research and scientific papers
Asymmetric domino Michael-Henry reaction of 1,2-diones with nitroolefins catalyzed by a chiral bisoxazolidine-Ni(acac)2 complex
Liang, Qian,He, Junpeng,Ni, Bukuo
, p. 1146 - 1149 (2014/11/08)
The asymmetric domino Michael-Henry reaction of 1,2-cyclohexadione with nitroolefins catalyzed by chiral ligand bisoxazolidine 1 and Ni(acac) 2 has been developed. This process provided highly functionalized chiral bicycle[3,2,1] octane derivatives with the generation of four new stereogenic centers in high yields (76-99%), and with excellent enantioselectivities (up to 99%) and good diastereoselectivities (up to 9:1) under mild reaction conditions. The procedure presented is simple and makes this method suitable for practical use.
New approach to the preparation of bicyclo octane derivatives via the enantioselective cascade reaction catalyzed by chiral diamine-Ni(OAc) 2 complex
Li, Wenyi,Liu, Xiaodong,Mao, Zhifeng,Chen, Qiao,Wang, Rui
supporting information; experimental part, p. 4767 - 4773 (2012/08/08)
A highly efficient catalyst system assembled from enantiomerically pure diaminocyclohexane and Ni(OAc)2 is, for the first time, used to catalyze the cascade Michael-Henry reaction of various diones and substituted nitroalkenes. A series of polyfunctionalized bicyclo[3.2.1]octane derivatives containing four stereogenic centers are prepared with excellent enantioselectivities (up to >99% ee) and diastereoselectivities (up to 50:1 dr) with high yields. In addition, via this chiral diamine-Ni(OAc)2 catalyst system, the base-induced epimerization leading to the decrease of stereoselectivity can be prevented.
