138306-24-8Relevant articles and documents
Metathesis for catalyst design: Metacatalysis
Khumsubdee, Sakunchai,Burgess, Kevin
, p. 1326 - 1335 (2014/02/14)
Prior studies have shown an effective way to produce diverse ligand sets for catalyst discovery is by using mixtures of monodentate forms to generate catalysts in situ. Research described here was performed to illustrate that alkene-functionalized monodentate ligands could be used in this way and in another that increases the diversity of the ligand library in an interesting way. Specifically, we hypothesized that as well as being used as monomers, these alkenes could be cross metathesized in situ immediately before the catalysis step. This combination of metathesis to form ligands in situ, then catalysis is referred to here as metacatalysis. In the event, a library of quinidine and quinine alkaloid-derived phosphites were tested as mixtures of monomers and dimers formed via metathesis in situ. The data obtained illustrated that metacatalysis can be used to identify ligands that positively and negatively modulate enantioselectivities in iridium-mediated hydrogenations of α,β-unsaturated carboxylic acid derivatives, relative to the mixtures of the monomeric forms used.
A comparison between oxazoline-imidazolinylidene, -imidazolylidine, -benzimidazolylidene hydrogenation catalysts
Khumsubdee, Sakunchai,Fan, Yubo,Burgess, Kevin
, p. 9969 - 9974 (2013/10/22)
Imidazolinylidene, imidazolylidine, benzimidazolylidene complexes 1a-c were prepared and tested in asymmetric hydrogenations of a series of largely unfunctionalized alkenes. Similarities and differences in the catalytic performance of these complexes were rationalized in terms of the predicted mechanisms of these reactions, and their relative tendencies to generate protons under the hydrogenation conditions.
Total syntheses of amphidinolide H and G
Fuerstner, Alois,Bouchez, Laure C.,Funel, Jacques-Alexis,Liepins, Vilnis,Poree, Francois-Hugues,Gilmour, Ryan,Beaufils, Florent,Laurich, Daniel,Tamiya, Minoru
, p. 9265 - 9270 (2008/12/22)
(Chemical Equation Presented) Eureka! The first conquest of the exceptionally potent cytotoxic agent amphidinolide H, which exhibits activity in the picomolar range against human epidermoid cancer cells, was long overdue. The successful route critically h
