138310-59-5Relevant academic research and scientific papers
Synthesis and absolute stereochemistry of thysanone
Donner, Christopher D.,Gill, Melvyn
, p. 3921 - 3924 (1999)
The structure and absolute stereochemistry of thysanone 3, a fungal benzoisochromanquinone with potent human rhinovirus 3C-protease inhibitory activity, is established by the total synthesis of its antipode 1 from (S)- propylene oxide.
Pigments of fungi. Part 68. Synthesis and absolute configuration of thysanone2
Donner, Christopher D.,Gill, Melvyn
, p. 938 - 948 (2002)
The (1R,3S)-absolute stereochemistry of thysanone 1, a fungal benzoisochromanquinone with potent human rhinovirus 3C-protease inhibitory activity, is established for the first time by total synthesis of the natural product from ethyl (S)-lactate and CD co
Enantioselective synthesis of the 3C-protease inhibitor (-)-thysanone by a Staunton-Weinreb annulation strategy
Sperry, Jonathan,Tsz, Ying Yuen,Brimble, Margaret A.
experimental part, p. 2561 - 2569 (2009/12/25)
The total synthesis of (-)-thysanone is described. The key step involves the addition of an o-toluate anion to a lactone to create the naphthopyran framework (Staunton-Weinreb annulation). This synthesis further confirms the absolute stereochemistry of th
An efficient enantioselective synthesis of the 3C protease inhibitor (-)-thysanone
Sperry, Jonathan,Brimble, Margaret A.
scheme or table, p. 1910 - 1912 (2009/05/27)
The enantioselective synthesis of the 3C protease inhibitor (-)-thysanone is described. The key step is the o-toluate anion addition to an α,β-unsaturated δ-lactone. Spectroscopic analysis of the synthetic material confirms the 1R,3S stereochemistry of th
