1383116-33-3Relevant academic research and scientific papers
Transition-metal-free visible-light photoredox catalysis at room-temperature for decarboxylative fluorination of aliphatic carboxylic acids by organic dyes
Wu, Xinxin,Meng, Chunna,Yuan, Xiaoqian,Jia, Xiaotong,Qian, Xuhong,Ye, Jinxing
supporting information, p. 11864 - 11867 (2015/07/20)
We report herein an efficient, general and green method for decarboxylative fluorination of aliphatic carboxylic acids. By using a transition-metal-free, organocatalytic photoredox system, the reaction of various aliphatic carboxylic acids with the Select
Silver-catalyzed decarboxylative fluorination of aliphatic carboxylic acids in aqueous solution
Yin, Feng,Wang, Zhentao,Li, Zhaodong,Li, Chaozhong
supporting information; experimental part, p. 10401 - 10404 (2012/08/08)
Although fluorinated compounds have found widespread applications in the chemical and materials industries, general and site-specific C(sp3)-F bond formations are still a challenging task. We report here that with the catalysis of AgNO3, various aliphatic carboxylic acids undergo efficient decarboxylative fluorination with SELECTFLUOR reagent in aqueous solution, leading to the synthesis of the corresponding alkyl fluorides in satisfactory yields under mild conditions. This radical fluorination method is not only efficient and general but also chemoselective and functional-group- compatible, thus making it highly practical in the synthesis of fluorinated molecules. A mechanism involvinig Ag(III)-mediated single electron transfer followed by fluorine atom transfer is proposed for this catalytic fluorodecarboxylation.
