1383121-08-1Relevant articles and documents
Enantioselective iridium-catalyzed hydrogenation of α-arylcinnamic acids and synthesis of (S)-equol
Yang, Shuang,Zhu, Shou-Fei,Zhang, Can-Ming,Song, Song,Yu, Yan-Bo,Li, Shen,Zhou, Qi-Lin
, p. 5172 - 5178 (2012)
By using iridium catalyst based on chiral spiro phosphine-oxazoline ligands, the hydrogenation of α-arylcinnamic acids was accomplished under ambient pressure and low catalyst loading (as low as 0.01 mol %), providing useful 2,3-diarylpropionic acids in high yields with excellent enantioselectivities (up to 99% ee). A catalytic enantioselective synthesis of (S)-equol with the present hydrogenation reaction as a key step was accomplished starting from commercially available starting materials in six steps with 48.4% overall yield.
