1383151-21-0

Basic information

• Product Name: C₁₃H₁₇F₃O₂
• CAS NO: 1383151-21-0
• Molecular Weight: 262.272
• Mol File: 1383151-21-0.mol

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₇F₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₇F₃O₂(1383151-21-0)
• EPA Substance Registry System: C₁₃H₁₇F₃O₂(1383151-21-0)

Safety Data

• Hazardous Substances Data: 1383151-21-0(Hazardous Substances Data)

Upstream product

• 4286-55-9 1-bromo-6-hexanol 
• 444-30-4 2-(trifluoromethyl)phenol 

Downstream Products

• 1383151-75-4 C₁₃H₁₅F₃O₂ 
• 1383152-39-3 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-(6-(2-(trifluoromethyl)phenoxy)hexyl)piperidine-3,4,5-triol 

Relevant articles and documents

GLYCOLIPID INHIBITION USING IMINOSUGARS

The application provides iminosugars with a high activity and specificity for inhibiting ceramide glucosyltransferase.

Design, synthesis, and biological evaluation of N-Alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection

We recently described the discovery of oxygenated N-alkyl deoxynojirimycin (DNJ) derivative 7 (CM-10-18) with antiviral activity against dengue virus (DENV) infection both in vitro and in vivo. This imino sugar was promising but had an EC50 against DENV in BHK cells of 6.5 μM, which limited its use in in vivo. Compound 7 presented structural opportunities for activity relationship analysis, which we exploited and report here. These structure-activity relationship studies led to analogues 2h, 2l, 3j, 3l, 3v, and 4b-4c with nanomolar antiviral activity (EC50 = 0.3-0.5 μM) against DENV infection, while maintaining low cytotoxicity (CC50 > 500 μM, SI > 1000). In male Sprague-Dawley rats, compound 3l was well tolerated at a dose up to 200 mg/kg and displayed desirable PK profiles, with significantly improved bioavailability (F = 92 α 4%).