138321-99-0

Basic information

• Product Name: 6fapbp
• Synonyms: 4,4'-Bis(4-Amino-2-Trifluoromethylphenoxy)Biphenyl;6fapbp
• CAS NO: 138321-99-0
• Molecular Formula: C₂₆H₁₈F₆N₂O₂
• Molecular Weight: 504.4237392
• Mol File: 138321-99-0.mol

Chemical Properties

• Melting Point: 155-156 ºC
• Boiling Point: 554.793 °C at 760 mmHg
• Flash Point: 289.329 °C
• Appearance: /
• Density: 1.372
• PKA: 3.83±0.10(Predicted)
• CAS DataBase Reference: 6fapbp(CAS DataBase Reference)
• NIST Chemistry Reference: 6fapbp(138321-99-0)
• EPA Substance Registry System: 6fapbp(138321-99-0)

Safety Data

• Hazardous Substances Data: 138321-99-0(Hazardous Substances Data)

Usage

Uses

Used in Scientific Research:
6FAPBP is used as a research chemical for studying the effects of synthetic cannabinoids on the brain and behavior. It aids in understanding the mechanisms of action and potential therapeutic applications of cannabinoids.
Used in Pharmaceutical Development:
Although not approved for human consumption, 6FAPBP may contribute to the development of new pharmaceuticals targeting the cannabinoid receptors for various medical conditions. Its study can provide insights into the design of safer and more effective cannabinoid-based drugs.
Used in Toxicological Studies:
6FAPBP is employed in toxicological research to assess the risks and dangers associated with synthetic cannabinoids. This helps in understanding their potential for abuse and informing regulatory policies to protect public health.
Used in Neuropharmacology:
6FAPBP serves as a tool in neuropharmacological studies to explore the interactions between synthetic cannabinoids and the central nervous system. This can lead to a better understanding of the neurobiological basis of their psychoactive effects and potential therapeutic uses.
Used in Drug Testing and Detection:
6FAPBP is utilized in the development of drug testing methods and detection technologies to identify and monitor the presence of synthetic cannabinoids in biological samples, such as blood or urine.
Used in Forensic Analysis:
In forensic science, 6FAPBP is employed to analyze and identify synthetic cannabinoids in cases involving drug-related crimes or incidents, assisting in the investigation and prosecution of such cases.

Upstream product

• 92-88-6 4,4'-Dihydroxybiphenyl 
• 777-37-7 4-chloro-3-(trifluoromethyl)nitrobenzene 
• 94517-22-3 4,4'-bis(4-nitro-2-trifluoromethylphenoxy)biphenyl 

Relevant articles and documents

Synthesis and characterization of sulfonated polyimides containing trifluoromethyl groups as proton exchange membranes

A novel sulfonated diamine, 4,4′-bis(4-amino-3- trifluoromethylphenoxy) biphenyl 3,3′-disulfonic acid (F-BAPBDS), was successfully synthesized by nucleophilic aromatic substitution of 4,4′-dihydroxybiphenyl with 2-chloro-5-nitrobenzotrifluoride, followed by reduction and sulfonation. A series of sulfonated polyimides of high molecular weight (SPI-x, x represents the molar percentage of the sulfonated monomer) were prepared by copolymerization of 1,4,5,8-naphathlenetetracarboxylic dianhydride (NTDA) with F-BAPBDS and nonsulfonated diamine. Flexible and tough membranes of high mechanical strength were obtained by solution casting and the electrolyte properties of the polymers were intensively investigated. The copolymer membranes exhibited excellent oxidative stability due to the introducing of the CF3 groups. The SPI membranes displayed desirable proton conductivity (0.52 × 10-1-0.97 × 10-1 S·cm -1) and low methanol permeability (less than 2.8 × 10 -7 cm2·s-1). The highest proton conductivity (1.89 × 10-1 S·cm-1) was obtained for the SPI-90 membrane at 80°C, with an IEC of 2.12 mequiv/g. This value is higher than that of Nafion 117 (1.7 × 10-1 S·cm-1). Furthermore, the hydrolytic stability of the obtained SPIs is better than the BDSA and ODADS based SPIs due to the hydrophobic CF3 groups which protect the imide ring from being attacked by water molecules, in spite of its strong electron-withdrawing behaviors. Copyright

Novel ‘naked-eye’ Bis-Schiff base fluorescent chemosensors for sensitive detection of Zn2+ and bio-imaging in living cells

Novel chemosensors based on excited state intramolecular proton transfer chemosensors (F1, F3, F5) and reference dyes (F2, F4, F6) are presented in this work. Target dyes F1, F3 and F5 display high selectivity and sensitivity toward Zn2+ in solvents (such as EtOH, EtOH/PBS buffer) in the presence of competitive ions (K+, Na+, Ni2+, Pb2+, Mn2+, Mg2+, Hg2+, Cu2+,Cd2+, Cr3+, Fe3+). Sensing property for Zn2+ was studied by UV–Visible, fluorescence spectrophotometric analyses and Job's plot analyses. F1, F3 and F5 for Zn2+ detection revealed extremely low detection limit (67.2 nM), high anti-interference ability, and the immediate response. Furthermore, inverted fluorescence microscopy imaging experiment were also investigated, the results demonstrated that the probes have well cell membrane permeability and hypotoxicity. Simultaneously, due to the ability to adapt a wider range of pH, the probes could also image Zn2+ in live cells with remarkable fluorescence variation and provide a new method to visualize monitoring in live cells.