138332-40-8Relevant articles and documents
Copper catalyzed process for producing 4-substituted azetidinone derivatives
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, (2008/06/13)
A process for producing a 4-substituted azetidinone derivative represented by the following general formula ?III!: STR1 (wherein OR is a protected hydroxy group, Y is an alkyl group, an alkoxy group, a silyloxy group, a carbamoyloxy group, an amino group,
Copper-assisted substitution reaction for phenylthio group of a 4- phenylthioazetidinone derivative
Shimamoto,Inoue,Yoshida,Tanaka,Nakatsuka,Ishiguro
, p. 5887 - 5888 (2007/10/02)
The phenylthio group of 4-phenylthioazetidinone (1) was readily substituted with copper(I) salts of carboxylates, thiocarboxylates, and copper(I) enolates of malonates and β-ketoesters to give synthetic intermediates (3 and 4) for penem and carbapenem antibiotics.
A NOVEL SUBSTITUTION REACTION OF 4-SULFINYLAZETIDIN-2-ONE WITH SILYLATED HETERONUCLEOPHILES: AN EFFICIENT SYNTHESIS OF 4-HETEROFUNCTION SUBSTITUTED 3-(1-HYDROXY)ETHYLAZETIDIN-2-ONES
Kita, Yasuyuki,Shibata, Norio,Yoshida, Naoki,Tohjo, Takashi
, p. 2375 - 2378 (2007/10/02)
4-Sulfinylazetidin-2-one was reacted with silylated heteronucleophiles in the presence of a catalytic amount of zinc iodide to give the corresponding trans-4-heterofunction substituted azetidin-2-ones in high yields.