1383372-63-1Relevant academic research and scientific papers
Synthesis of Diverse N-Acryloyl Azetidines and Evaluation of Their Enhanced Thiol Reactivities
Palkowitz, Maximilian D.,Tan, Bo,Hu, Haitao,Roth, Kenneth,Bauer, Renato A.
, p. 2270 - 2273 (2017/05/12)
Acyl azetidines exhibit nonplanar hybridization, leading to lower amide-like character of the corresponding (O)C-N bonds. This impacts N-acryloyl azetidines by producing enhanced electrophilicy at appended Michael acceptors. Herein, reactivity data are reported in the presence of glutathione (GSH) in phosphate buffer (pH 7.4) at 37 °C. Wide reactivity ranges are observed by varying substitution at the Michael acceptor or by modulating the electron-withdrawing character of substituents at the C3 position of the azetidine.
Methods of using pyruvate kinase activators
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Page/Page column 67; 68, (2016/08/23)
Described herein are methods for using compounds that activate pyruvate kinase.
NOVEL N- (4- (AZETIDINE - 1 - CARBONYL) PHENYL) - (HETERO - ) ARYLSULFONAMIDE DERIVATIVES AS PYRUVATE KINASE M2 (PMK2) MODULATORS
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Page/Page column 39-40, (2012/06/30)
Compounds of general Formula (I), and compositions comprising compounds of general formula I that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of canc
