1383380-99-1

Basic information

• Product Name: C₁₆H₁₃F₃N₂O₂
• Synonyms: C₁₆H₁₃F₃N₂O₂
• CAS NO: 1383380-99-1
• Molecular Weight: 322.287
• Mol File: 1383380-99-1.mol

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₃F₃N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₃F₃N₂O₂(1383380-99-1)
• EPA Substance Registry System: C₁₆H₁₃F₃N₂O₂(1383380-99-1)

Safety Data

• Hazardous Substances Data: 1383380-99-1(Hazardous Substances Data)

Relevant articles and documents

Piperazine amide linker for cyclative cleavage from solid support: Traceless synthesis of dihydroquinoxalin-2-ones

A piperazine amide linker for cyclative cleavage from solid support and its use in the traceless solid-phase synthesis of dihydroquinoxalinones are described. Piperazine was attached to Wang resin via a carbamate linkage and acylated with Fmoc-amino acids. Following Fmoc group removal, resin-bound amines were reacted with 1-fluoro-2-nitrobenzenes. The nitro group of the resulting 2-nitroanilines was reduced, and acyclic precursors, in contrast to traditional ester-type linkage, remained attached to the resin. Target dihydroquinoxalinones were obtained either by acid- or microwave-mediated cyclative cleavage. The synthesis provided crude compounds of high purity and enabled the preparation of stable immobilized linear intermediates. The linker is suitable for combinatorial synthesis of compound libraries.