1383439-06-2Relevant articles and documents
Synthesis, antitumor activity and SAR study of novel [1,2,4]triazino[4,5-a] benzimidazole derivatives
El-Nassan, Hala Bakr
, p. 22 - 27 (2012)
A series of novel 1,2,3,4-tetrahydro[1,2,4]triazino[4,5-a]benzimidazoles carrying variety of aryl and heteroaryl groups at position 1 were synthesized. The newly synthesized compounds were tested in vitro on human breast adenocarcinoma cell line (MCF7). Some of the test compounds showed potent antitumor activity, especially compound 3c [1-(2-chlorophenyl) derivative] which displayed the highest activity among the test compounds.