1383471-03-1Relevant articles and documents
Isoxazolo(aza)naphthoquinones: A new class of cytotoxic Hsp90 inhibitors
Bargiotti, Alberto,Musso, Loana,Dallavalle, Sabrina,Merlini, Lucio,Gallo, Grazia,Ciacci, Andrea,Giannini, Giuseppe,Cabri, Walter,Penco, Sergio,Vesci, Loredana,Castorina, Massimo,Milazzo, Ferdinando Maria,Cervoni, Maria Luisa,Barbarino, Marcella,Pisano, Claudio,Giommarelli, Chiara,Zuco, Valentina,De Cesare, Michelandrea,Zunino, Franco
, p. 64 - 75 (2012/07/30)
A series of 3-aryl-naphtho[2,3-d]isoxazole-4,9-diones and some of their 6-aza analogues were synthesized and found to inhibit the heat shock protein 90 (Hsp90). The compounds were tested for their binding to Hsp90 and for their effects on Hsp90 client pro