1383550-10-4Relevant academic research and scientific papers
New methodology for the synthesis of thiobarbiturates mediated by manganese(III) acetate
Bouhlel, Ahlem,Curti, Christophe,Vanelle, Patrice
, p. 4313 - 4325 (2012/07/01)
A three step synthesis of various thiobarbiturate derivatives 17-24 was established. The first step is mediated by Mn(OAc)3, in order to generate a carbon-carbon bond between a terminal alkene and malonate. Derivatives 1-8 were obtained in moderate to good yields under mild conditions. This key step allows synthesis of a wide variety of lipophilic thiobarbiturates, which could be tested for their anticonvulsive or anesthesic potential.
