1383571-75-2Relevant articles and documents
Synthesis of spirocyclic γ-lactones by cascade Beckwith-Dowd ring expansion/cyclization
Hierold, Judith,Lupton, David W.
, p. 3412 - 3415 (2012/08/28)
A range of spirocyclic γ-lactones have been prepared exploiting a Beckwith-Dowd ring expansion cascade involving 1-, 3-, 4-, and 5-carbon expansion of cyclopentanone and cyclohexanone followed by 5-exo-trig or 5-exo-dig cyclization. This radical cascade reaction can be achieved with various substrates to provide a broad range of γ-lactones spirofused to 6- to 10-membered cycloalkanones.