1383609-48-0

Upstream product

• 603-62-3 4-nitro-1H-isoindole-1,3(2H)-dione 
• 65911-46-8 2-carbamoyl-6-nitrobenzoic acid 
• 412341-84-5 2-methyl-5-nitro-4H-benzo[d][1,3]oxazin-4-one 
• 98-16-8 3-trifluoromethylaniline 
• 50573-74-5 6-nitroanthranilic acid 

Downstream Products

• 1383609-41-3 N-(2-methyl-4-oxo-3-(3-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-5-yl)pyrazine-2-carboxamide 
• 1383609-49-1 5-amino-2-methyl-3-(3-(trifluoromethyl)phenyl)quinazolin-4(3H)-one 
• 1383609-45-7 6-(2,3-dihydroxypropoxy)-N-(2-methyl-4-oxo-3-(3-(trifluoromethyl)phenyl)-3,4-dihydroquinazolin-5-yl)picolinamide 

Relevant academic research and scientific papers

QUINAZOLINONE AND RELATED ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.