1383625-75-9Relevant academic research and scientific papers
Sequential protocol for C(sp3)-H carboxylation with CO 2: Transition-metal-catalyzed benzylic C-H silylation and fluoride-mediated carboxylation
Mita, Tsuyoshi,Michigami, Kenichi,Sato, Yoshihiro
, p. 3462 - 3465 (2012/08/08)
One of the most challenging transformations in current organic chemistry is the catalytic carboxylation of a C(sp3)-H bond using CO2 gas, an inexpensive and ubiquitous C1 source. A sequential protocol for C(sp3)-H carboxylation by employing a nitrogen-directed, metal-assisted, C-H activation/catalytic silylation reaction in conjunction with fluoride-mediated carboxylation with CO2 was established. The carboxylation proceeded only at the benzylic C(sp3)-Si bond, not at the aromatic C(sp2)-Si, which is advantageous for further manipulations of the products.
