1383658-35-2Relevant academic research and scientific papers
Efficient approach to 1,2-diazepines via formal diazomethylene insertion into the C-C bond of cyclobutenones
Sugimoto, Kenji,Hayashi, Rie,Nemoto, Hideo,Toyooka, Naoki,Matsuya, Yuji
, p. 3510 - 3513 (2012/07/31)
Efficient monocyclic 1,2-diazepine formation via a tandem electrocyclization reaction of cyclobutenones with lithiodiazoacetate is demonstrated. The reaction proceeds through an oxy anion-accelerated 4π-ring opening of cyclobutene followed by an 8π-ring closure of the resultant oxy anion-substituted diazo-diene under mild conditions to furnish a 1,2-diazepine via formal diazomethylene insertion into the C-C bond of cyclobutenone.
