1383659-91-3

Basic information

• Product Name: N'-(1-benzyl-2-cyano-1H-indol-3-yl)-N,N-dimethylformimidamide
• Synonyms: N'-(1-benzyl-2-cyano-1H-indol-3-yl)-N,N-dimethylformimidamide
• CAS NO: 1383659-91-3
• Molecular Weight: 302.379
• Mol File: 1383659-91-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N'-(1-benzyl-2-cyano-1H-indol-3-yl)-N,N-dimethylformimidamide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-(1-benzyl-2-cyano-1H-indol-3-yl)-N,N-dimethylformimidamide(1383659-91-3)
• EPA Substance Registry System: N'-(1-benzyl-2-cyano-1H-indol-3-yl)-N,N-dimethylformimidamide(1383659-91-3)

Safety Data

• Hazardous Substances Data: 1383659-91-3(Hazardous Substances Data)

Upstream product

• 1192690-93-9 3-amino-1H-indole-2-carbonitrile 
• 2016-04-8 N,N-dimethylformamide dibenzyl acetal 

Relevant articles and documents

Exploring kinase inhibition properties of 9hpyrimido[5,4-b]- and [4,5-b]indol-4-amine derivatives

We previously highlighted the interest in 6,5,6-fused tricyclic analogues of 4-aminoquinazolines as kinase inhibitors in the micromolar to the nanomolar range of IC50 values. For the generation of chemical libraries, the formamide-mediated cyclization of the cyanoamidine precursors was carried out under microwave irradiation in an eco-friendly approach. In order to explore more in-depth the pharmacological interest in such tricyclic skeletons, the central five member ring, i.e., thiophène or furan, was replaced by a pyrrole to afford 9H-pyrimido[5,4-b]- and [4,5-b]indol-4-amine derivatives inspired from harmine. The inhibitory potency of the final products was determined against four protein kinases (CDK5/p25, CK1δ/ε, GSK3α/β and DYRK1A). As a result, we have identified promising compounds targeting CK1δ/ε and DYRK1A and displaying micromolar and submicromolar IC50 values.