1383663-42-0

Basic information

• Product Name: (Z)-2-ethyl-1-(4-methoxystyryl)-4-methyl-1H-imidazole
• Synonyms: (Z)-2-ethyl-1-(4-methoxystyryl)-4-methyl-1H-imidazole
• CAS NO: 1383663-42-0
• Molecular Weight: 242.321
• Mol File: 1383663-42-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-2-ethyl-1-(4-methoxystyryl)-4-methyl-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-ethyl-1-(4-methoxystyryl)-4-methyl-1H-imidazole(1383663-42-0)
• EPA Substance Registry System: (Z)-2-ethyl-1-(4-methoxystyryl)-4-methyl-1H-imidazole(1383663-42-0)

Safety Data

• Hazardous Substances Data: 1383663-42-0(Hazardous Substances Data)

Upstream product

• 931-36-2 2-ethyl-4-methyl-1H-imidazole 
• 768-60-5 4-methoxyphenylacetylen 

Relevant articles and documents

Base-mediated selective synthesis of diversely substituted N-heterocyclic enamines and enaminones by the hydroamination of alkynes

Regio- and stereoselective alkynylation of various N-heterocycles 1a-l using potassium and cesium salts in DMSO is described. Terminal alkynes 2a-k and internal alkynes 4a-f provided the kinetically stable Z-enamines 3a-l and 5a-i in good to excellent yields using KOH at 120 °C. Addition of heterocyclic amines to 1,3- and 1,4-diethynylbenzene 6a-b provided the mixture of E/Z isomers with KOH; however, with Cs2CO3 selectively Z-isomers 7ab-db were obtained by the hydroamination at one triple bond. This developed methodology also provides an easy and novel access for the synthesis of enaminones 10a-c. The detailed work also supports the formation of cis-isomer by preferential addition of o-haloarylalkynes followed by intramolecular C2 arylation in the copper-catalyzed tandem synthesis of indolo and pyrrolo[2,1-a]isoquinolines.