1383672-75-0Relevant academic research and scientific papers
Mechanism-based design, synthesis and biological studies of N 5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents
Zhang, Zhili,Tian, Chao,Zhou, Shouxin,Wang, Wei,Guo, Ying,Xia, Jie,Liu, Zhenming,Wang, Biao,Wang, Xiaowei,Golding, Bernard T.,Griff, Roger J.,Du, Yansheng,Liu, Junyi
, p. 228 - 236 (2013/02/22)
A number of 8-deazatetrahydrofolates bearing electrophilic groups on N 5 were designed and synthesized based on the action mechanism of methionine synthase, and their biological activities were investigated as well. Compounds (11b, 12b and 16)
