1383706-89-5Relevant academic research and scientific papers
Ortho-Induced transition-metal-free C-arylation cyclization reaction for the synthesis of polysubstituted isocoumarins
Liu, Lei,Hu, Jie,Wang, Xiang-Chuan,Zhong, Mei-Jin,Liu, Xue-Yuan,Yang, Shang-Dong,Liang, Yong-Min
supporting information; experimental part, p. 5391 - 5395 (2012/09/08)
A new protocol for the synthesis of polysubstituted isocoumarins from 2-iodobenzoic acid and β-diketone compounds has been developed. The occurrence of C-arylation cyclization reaction in transition-metal-free systems and ortho-induced substrates has been exploited. Reactions using these inexpensive conditions have displayed high functional group tolerance and excellent yields.
