1383715-91-0Relevant academic research and scientific papers
Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo
Honda, Ayako,Harrington, Edmund,Cornella-Taracido, Ivan,Furet, Pascal,Knapp, Mark S.,Glick, Meir,Triantafellow, Ellen,Dowdle, William E.,Wiedershain, Dmitri,Maniara, Wieslawa,Moore, Christine,Finan, Peter M.,Hamann, Lawrence G.,Firestone, Brant,Murphy, Leon O.,Keaney, Erin P.
, p. 72 - 76 (2016/02/03)
Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components. Until recently the study of autophagy has been hampered by the lack of reliable pharmacological tools, but selective inhibitors are now available to modulate the PI 3-kinase VPS34, which is required for autophagy. Here we describe the discovery of potent and selective VPS34 inhibitors, their pharmacokinetic (PK) properties, and ability to inhibit autophagy in cellular and mouse models.
BI-HETEROARYL COMPOUNDS AS VPS34 INHIBITORS
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Page/Page column 45, (2012/07/13)
The present invention includes novel methods of treating a disease or disorder characterized by hyperactivity of Vps34, and compound as Vps34 inhibitors; particularly compounds of Formula I or a pharmaceutically acceptable salt thereof, as well as methods
