1383737-75-4Relevant academic research and scientific papers
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists
Schroeder, Gretchen M.,Wei, Donna,Banfi, Patrizia,Cai, Zhen-Wei,Lippy, Jonathan,Menichincheri, Maria,Modugno, Michele,Naglich, Joseph,Penhallow, Becky,Perez, Heidi L.,Sack, John,Schmidt, Robert J.,Tebben, Andrew,Yan, Chunhong,Zhang, Liping,Galvani, Arturo,Lombardo, Louis J.,Borzilleri, Robert M.
scheme or table, p. 3951 - 3956 (2012/07/03)
5-Butyl-1,4-diphenyl pyrazole and 2-amino-5-chloro pyrimidine acylsulfonamides were developed as potent dual antagonists of Bcl-2 and Bcl-xL. Compounds were optimized for binding to the I88, L92, I95, and F99 pockets normally occupied by pro-apoptotic pro
