1383791-86-3Relevant academic research and scientific papers
Toward an enantioselective synthesis of (-)-zampanolide: Preparation of the C9-C20 region
Wilson, Matthew R.,Taylor, Richard E.
, p. 3408 - 3411 (2012/09/07)
Progress toward the synthesis of the microtubule-stabilizing agent, (-)-zampanolide, is reported. Construction of the 2,6-cis-tetrahydropyran ring was accomplished utilizing ether transfer methodology in conjunction with an intramolecular radical cyclization reaction. Efficient installation of the C16-C20 side chain relied on a one-pot cross-metathesis/olefination sequence, Sharpless epoxidation, and selective reduction of a vinyl epoxide.
