13838-29-4

Basic information

• Product Name: 4-chloro-6-phenoxy-N-phenyl-1,3,5-triazin-2-amine
• CAS NO: 13838-29-4
• Molecular Formula: C₁₅H₁₁ClN₄O
• Molecular Weight: 298.727
• Mol File: 13838-29-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 496.5°C at 760 mmHg
• Flash Point: 254.1°C
• Density: 1.372g/cm³
• Vapor Pressure: 5.39E-10mmHg at 25°C
• Refractive Index: 1.669
• CAS DataBase Reference: 4-chloro-6-phenoxy-N-phenyl-1,3,5-triazin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-6-phenoxy-N-phenyl-1,3,5-triazin-2-amine(13838-29-4)
• EPA Substance Registry System: 4-chloro-6-phenoxy-N-phenyl-1,3,5-triazin-2-amine(13838-29-4)

Safety Data

• Hazardous Substances Data: 13838-29-4(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 2272-40-4 2-phenylamino-4,6-dichloro-s-triazine 
• 108-95-2 phenol 

Relevant articles and documents

Synthesis and structure-activity relationship study of triazine-based inhibitors of the DNA binding of NF-κB

Nuclear transcription factor nuclear factor-kappa B (NF-κB) has diverse pathophysiological functions, and NF-κ B inhibitors are considered to be candidates for multiple therapeutic applications. We previously reported a novel triazine-based NF-κB inhibitor, 2-anilino-4,6-dichloro-1,3,5- triazine (NI241), that directly inhibits DNA binding of NF-κB. Here, we report synthesis of a series of triazine derivatives and evaluation of their structure-activity relationships for NF-κB inhibition. We found that 2-amino-4,6-dichloro-1,3,5-triazine substructure is essential for the inhibitory activity of the lead compound NI241, and modification of NI241 by introduction of an m-methoxy substituent on the phenyl ring afforded the more potent derivative 28. The structure-activity relationships identified in this study suggested a possible mechanism of irreversible NF-κB inhibition by NI241, and should be helpful in the design of other NF-κB inhibitors.