1383800-57-4

Basic information

• Product Name: ethyl 4-butyrylbenzoate
• Synonyms: ethyl 4-butyrylbenzoate
• CAS NO: 1383800-57-4
• Molecular Formula: C₁₃H₁₆O₃
• Molecular Weight: 220.26434
• Mol File: 1383800-57-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 4-butyrylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-butyrylbenzoate(1383800-57-4)
• EPA Substance Registry System: ethyl 4-butyrylbenzoate(1383800-57-4)

Safety Data

• Hazardous Substances Data: 1383800-57-4(Hazardous Substances Data)

Upstream product

• 5798-75-4 Ethyl 4-bromobenzoate 
• 123-72-8 butyraldehyde 
• 1355533-73-1 ethyl 4-(1-hydroxybutyl)benzoate 
• 51934-41-9 4-iodobenzoic acid ethyl ester 

Downstream Products

• 1383800-60-9 ethyl 4-(1-(2-(4-(trifluoromethyl)phenyl)pyrimidin-5-ylamino)butyl)benzoate 
• 1393127-04-2 ethyl 3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoate 
• 1393127-01-9 4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzoic acid 
• 1393122-96-7 (+/-)-3-(4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoic acid 
• 1393124-41-8 3-(4-(1-(2-(4-(trifluoromethyl)-1H-pyrazol-1-yl)pyrimidin-5-ylamino)butyl)benzamido)propanoic acid 
• 1432500-06-5 C₂₃H₂₄F₃N₅O₃ 
• 1393122-65-0 (+/-)-3-(4-(1-(6-(4-(trifluoromethyl)-1H-pyrazol-1-yl)pyridine-3-ylamino)butyl)benzamido)propanoic acid 
• 1393122-92-3 (+/-)-3-(4-(1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoic acid 
• 1393123-03-9 (+/-)-3-(4-(1-(4-(4-(trifluoromethyl)-1H-imidazol-1-yl)phenylamino)butyl)benzamido)propanoic acid 
• 1393124-08-7 (S)-3-(4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzamido)propanoic acid 
• 1393131-62-8 C₂₈H₃₂F₃N₃O₄ 
• 1393126-81-2 C₁₆H₂₃NO₄ 
• 1393126-80-1 (R)-4-(1-hydroxybutyl)benzoic acid 
• 1393125-60-4 C₁₃H₁₈O₃ 

Relevant articles and documents

Acylation of aryl halides and α-bromo acetates with aldehydes enabled by nickel/tbadt cocatalysis

In this protocol aryl halides and α-bromo acetates are efficiently cross-coupled with an array of (hetero)aromatic and aliphatic aldehydes under the cooperative catalysis of nickel and tetrabutylammonium decatungstate as a hydrogen-atom-transfer photocatalyst. This method provides a concise approach to a variety of ketones with high compatibility of various functional groups.

The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus

A novel and potent small molecule glucagon receptor antagonist for the treatment of diabetes mellitus is reported. This candidate, (S)-3-[4-(1-{3,5- dimethyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenoxy}butyl)benzamido] propanoic acid, has lower molecular weight and lipophilicity than historical glucagon receptor antagonists, resulting in excellent selectivity in broad-panel screening, lower cytotoxicity, and excellent overall in vivo safety in early pre-clinical testing. Additionally, it displays low in vivo clearance and excellent oral bioavailability in both rats and dogs. In a rat glucagon challenge model, it was shown to reduce the glucagon-elicited glucose excursion in a dose-dependent manner and at a concentration consistent with its rat in vitro potency. Its properties make it an excellent candidate for further investigation.

GLUCAGON RECEPTOR MODULATORS

The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucagon.