1383814-91-2Relevant academic research and scientific papers
A protocol for an asymmetric synthesis of γ-amino acids
Rajender Reddy, Leleti,Prasad, Kapa,Prashad, Mahavir
experimental part, p. 6296 - 6301 (2012/10/08)
A new and practical method for the asymmetric synthesis of γ-amino acids from β,γ-butenolides by an in situ esterification, condensation, and reduction in a one-pot procedure is described. This method is quite general for the preparation of both enantiomers of aryl or aliphatic γ-amino acids in high yields. These γ-amino-acid derivatives were also shown to be versatile synthetic intermediates for further transformations by their conversion to γ-lactams, δ-amino alcohols, and hydrolysis products in high yields with no racemization.
