1383816-95-2

Upstream product

• 1383822-31-8 (1R,3S,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octane 
• 1427-06-1 methyl 6-fluoropyridine-3-carboxylate 
• 1103500-32-8 methyl 5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole-4-carboxylate 

Downstream Products

• 1383816-96-3 6-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]oct-8-yl)nicotinic acid 

Relevant academic research and scientific papers

Isoxazole derivative, pharmaceutical composition containing isoxazole derivative, and preparation method and application thereof

The present invention belongs to the field of pharmaceutical chemistry, and generally relates to an isoxazole derivative, and stereoisomers, tautomers, polymorphs, solvates (such as hydrates), esters, metabolites, N-oxides and chemically protected forms and prodrugs thereof, or pharmaceutically acceptable salts thereof. The invention also relates to a preparation method of the compound, a pharmaceutical composition containing the compound and application of the compound and the pharmaceutical composition in treating diseases or conditions mediated by farnesoid X receptor (FXR).

COMPOSITIONS AND METHODS FOR MODULATING FXR

The present invention relates to compounds of Formula (I), a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesiod X receptors (FXR).