1383850-09-6

Basic information

• Product Name: C₂₇H₂₈N₂O₅S
• Synonyms: C₂₇H₂₈N₂O₅S
• CAS NO: 1383850-09-6
• Molecular Weight: 492.596
• Mol File: 1383850-09-6.mol

Chemical Properties

• CAS DataBase Reference: C₂₇H₂₈N₂O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₂₈N₂O₅S(1383850-09-6)
• EPA Substance Registry System: C₂₇H₂₈N₂O₅S(1383850-09-6)

Safety Data

• Hazardous Substances Data: 1383850-09-6(Hazardous Substances Data)

Upstream product

• 331852-88-1 (±)-2,3,4,9-tetrahydro-1-(3,4,5-trimethoxyphenyl)-1H-pyrido[3,4-b]indole 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 499109-72-7 1-(3',4,'5'-trimethoxyphenyl)-3,4-dihydro-9H-β-carboline 

Relevant articles and documents

Mild and efficient syntheses of 1-aryl-3,4-dihydroisoquinolines and 1-aryl-3,4-dihydro-β-carbolines via regiospecific β-eliminations of the corresponding N-tosyl-1,2,3,4-tetrahydroisoquinolines and N-tosyl-1,2,3,4-tetrahydro-β-carbolines

(Chemical Equation Presented) Treatment of N-tosyl-1-aryl-1,2,3,4- tetrahydro-isoquinolines or N-tosyl-1-aryl-1, 2,3,4-tetrahydro-β-carbolines with a strong base such as NaOH or KOH at 70 °C in dimethylsulfoxide (DMSO) produced 1-aryl-3,4-dihydroisoquinolines or 1-aryl-3,4-dihydro-β- carbolines in good yields via mild and regiospecific β-eliminations. A dramatic solvent effect was observed, DMSO was crucial for the reactions. The temperature is also crucial for the reactions and should be kept between 60 and 80 °C. Copyright Taylor & Francis Group, LLC.