138386-71-7

Basic information

• Product Name: Benzenamine, 2-[(1E)-2-(4-pyridinyl)ethenyl]-
• Synonyms: 2-[2-(4-pyridyl)ethenyl]aniline;(E)-2-(2-(pyridin-4-yl)vinyl)aniline;(E)-4-(o-aminostyryl)pyridine;2-(2-[4]Pyridyl-vinyl)-anilin;2-[2-(pyridin-4-yl)ethenyl]aniline;2-(2-[4]pyridyl-vinyl)-aniline
• CAS NO: 138386-71-7
• Molecular Formula: C13H12N2
• Molecular Weight: 196.252
• Mol File: 138386-71-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenamine, 2-[(1E)-2-(4-pyridinyl)ethenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 2-[(1E)-2-(4-pyridinyl)ethenyl]-(138386-71-7)
• EPA Substance Registry System: Benzenamine, 2-[(1E)-2-(4-pyridinyl)ethenyl]-(138386-71-7)

Safety Data

• Hazardous Substances Data: 138386-71-7(Hazardous Substances Data)

Upstream product

• 138457-93-9 4-(o-nitrostyryl)pyridine 
• 100-43-6 4-vinylpyridine 
• 615-36-1 2-bromoaniline 

Downstream Products

• 105972-24-5 2-[2-(4-pyridinyl)ethyl]aniline 
• 173528-92-2 (E)-4-[2-{2-[N-(4-methoxybenzenesulfonyl)amino]phenyl}ethenyl ]pyridine 

Relevant articles and documents

Inhibitory effect of cytotoxic nitrogen-containing heterocyclic stilbene analogues on VEGF protein secretion and VEGF, hTERT and c-Myc gene expression

A group of 21 nitrogen-containing heterocyclic stilbene derivatives, prepared by means of Heck coupling reactions, has been investigated for their cytotoxicity as well as their ability to inhibit the production of the vascular endothelial growth factor (VEGF) and the activation of telomerase. The ability of these compounds to inhibit proliferation of two tumoral cell lines (HT-29 and MCF-7) and one non-tumoral cell line (HEK-293) was first determined. Subsequently, we determined the capacity of the compounds to inhibit the secretion of VEGF in the aforementioned cell lines and downregulate the expression of the VEGF, hTERT and c-Myc genes, of which the latter two are involved in controlling the activation of telomerase.

Aminostilbazole derivative and medicine

The invention relates to an aminostilbazole derivative of the following formula or a hydrate thereof, and a salt thereof. STR1 wherein R1 and R2 each represents hydrogen etc.; R3, R4, R13, and R14 each represents hydrogen, C1-3 acyl, halogen, hydroxy etc.; R5 represents hydrogen or hydroxy-substituted C1-3 alkyl etc.; R6 represents benzenesulfonyl substituted by C1-3 alkoxy etc.; ring Y represents phenyl etc.; ring Z represents 4-pyridyl, its oxide etc. The compound is useful or the treatment of various malignant tumors.