1383935-63-4Relevant academic research and scientific papers
Evaluation of the antimicrobial activity of some 4H-pyrano[3,2-h]- quinoline,7H-pyrimido[4′,5′:6,5]pyrano[3,2-h]quinoline derivatives
Mohamed, Hany M.,Radini, Ibrahim A.,Al-Ghamdi, Abdullah M.,El-Agrody, Ahmed M.
, p. 758 - 775 (2013/12/04)
Several 4H-pyrano[3,2-h]quinolone (3, 5, 7, 8, 10, 11, 14, 15, 16 and 17) and 7H-pyrimido[4′,5′:-6,5]pyrano[3,2-h]quinoline derivatives (9, 12, 13, 18) were prepared. These compounds were tested in vitro for their antimicrobial activity to show congruent results against the most tested microorganisms as compared with the standards Ampicillin, Streptomycin, Mycostatine and Clotrimazole. The structure activity relationship (SAR) studies of 3 and its analog compounds revealed higher potent antimicrobial activity against the most tested microorganisms. These data indicated that the activity of compounds was considerably attributed to the presence of the electrondonating groups in combination with the electron-withdrawing groups in 4H-pyrano[3,2-h]quinoline moiety. Incorporating a pyrimidine nucleus with pyranoquinoline moiety resulted in changing the potency for some compound. The structures of these compounds were established on the basis of spectral data. 2013 Bentham Science Publishers.
Synthesis and antitumor activities of 4H-Pyrano[3,2-h]quinoline-3- carbonitrile, 7H-Pyrimido[4',5':6,5]pyrano[3,2-h]quinoline, and 14HPyrimido[4',5':6,5]pyrano[3,2-h][1,2,4]triazolo[1,5-c]quinoline derivatives
Al-Ghamdi, Abdullah Megbas,Abd El-Wahab, Ashraf Hassan Fekry,Mohamed, Hany Mostafa,El-Agrody, Ahmed Mohamed
, p. 459 - 470 (2012/08/08)
Several 4H-pyrano [3,2-h] quinoline 3,4,7-9, 7H-pyrimido[4',5':6,5] pyrano[3,2-h]quinoline 10a,b and 14Hpyrimido[4',5':6,5]pyrano[3,2-h][1,2,4] triazolo[1,5-c]quinoline 11a-c derivatives were obtained by treatment of (E) 2-(4-chlorostyryl)-8-hydroxyquinoline 1, (E) 2-amino-4-(4-chlorophenyl)-9-(4- chlorostyryl)-4H-pyrano[3,2-h]quinoline-3-carbonitr-ile 3 or (E) 9-amino-7-(4-chlorophenyl)-2-(4-chlorostyryl)-8-imino-8,9-dihydro-7H-pyrimido- [4',5':6,5]pyrano [3,2-h]quinoline 10b with different electrophiles followed by nucleophilic reagents. Structures of these compounds were established on the basis of IR, 1H NMR, 13C NMR, 13C NMR-DEPT, 13C NMR-APT and MS data. The antitumor activity of the synthesized compounds was investigated and compared with that of the standard drug vinblastine, a well-known anticancer drug, using MTT colorimetric assay. Among them, compounds 10b and 3 showed the most potent activity against the human breast tumor cells (MCF-7) and the human lung carcinoma cells (HCT), while compound 10b exhibited the most potent activity against the human hepatocellular carcinoma cells (HepG-2). The structure-activity relationships are discussed.
